› 2j0j

X-ray diffraction
2.8Å resolution

Crystal structure of a fragment of focal adhesion kinase containing the FERM and kinase domains.

Released:
DOI: 10.2210/pdb2j0j/pdb
PDB entry 2j0j coloured by chain, front view.
PDB entry 2j0j coloured by chain, side view.
PDB entry 2j0j coloured by chain, top view.
Source organism: Gallus gallus
Primary publication:
Structural basis for the autoinhibition of focal adhesion kinase.
Lietha D, Cai X, Ceccarelli DF, Li Y, Schaller MD, Eck MJ
Cell 129 1177-87 (2007)
PMID: 17574028

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-169484 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Focal adhesion kinase 1 Chain: A
Molecule details ›
Chain: A
Length: 656 amino acids
Theoretical weight: 75.35 KDa
Source organism: Gallus gallus
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q00944 (Residues: 31-686; Coverage: 62%)
Gene names: FAK, FAK1, PTK2
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand 4ST 1 x 4ST
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: C2221
Unit cell:
a: 67.532Å b: 91.275Å c: 250.715Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.22 0.217 0.274
Expression system: Trichoplusia ni

Quick links

Citations

78 review citations

Cell adhesion: integrating cytoskeletal dynamics and cellular tension.
Parsons et al. (2010)
77 more

21 mentions without citation

FAK Structure and Regulation by Membrane Interactions and Force in Focal Adhesions.
Tapial Martínez et al. (2020)
20 more