2j4w

X-ray diffraction
2.5Å resolution

Structure of a Plasmodium vivax apical membrane antigen 1-Fab F8.12.19 complex

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-176389 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Apical membrane antigen 1 Chain: D
Molecule details ›
Chain: D
Length: 445 amino acids
Theoretical weight: 51.36 KDa
Source organism: Plasmodium vivax
Expression system: Komagataella pastoris
UniProt:
  • Canonical: Q9TY14 (Residues: 1-445; Coverage: 100%)
Gene name: AMA-1
Sequence domains: Apical membrane antigen 1
Ig-like domain-containing protein Chain: H
Molecule details ›
Chain: H
Length: 225 amino acids
Theoretical weight: 24.19 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: Q569B4 (Residues: 20-123, 124-244; Coverage: 50%)
Gene name: Ighg
Sequence domains:
Structure domains: Immunoglobulins
Ig-like domain-containing protein Chain: L
Molecule details ›
Chain: L
Length: 213 amino acids
Theoretical weight: 23.29 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: Q5XFY8 (Residues: 23-235; Coverage: 100%)
Sequence domains:
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-2
Spacegroup: P63
Unit cell:
a: 171.787Å b: 171.787Å c: 44.748Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.19 0.187 0.241
Expression system: Komagataella pastoris