› 2j5z

X-ray diffraction
1.73Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131089 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ficolin-3 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 221 amino acids
Theoretical weight: 25.11 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: O75636 (Residues: 79-299; Coverage: 80%)
Gene names: FCN3, FCNH, HAKA1
Sequence domains: Fibrinogen beta and gamma chains, C-terminal globular domain
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand CA 3 x CA
Ligand GAL 1 x GAL
Ligand ACT 1 x ACT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-1
Spacegroup: P41212
Unit cell:
a: 62.2Å b: 62.2Å c: 345.49Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.204 0.202 0.233
Expression system: Trichoplusia ni

Quick links

Citations

32 review citations

An integrated view of humoral innate immunity: pentraxins as a paradigm.
Bottazzi et al. (2010)
31 more

2 mentions without citation

Correlating structure and function during the evolution of fibrinogen-related domains.
Doolittle et al. (2012)
1 more