› 2j7l

X-ray diffraction
2.6Å resolution

E. coli P Pilus chaperone PapD in complex with a pilus biogenesis inhibitor, pilicide 2c

Released:
DOI: 10.2210/pdb2j7l/pdb
Model geometry
Data not analysed
Fit model/data
PDB entry 2j7l coloured by chain, front view.
PDB entry 2j7l coloured by chain, side view.
PDB entry 2j7l coloured by chain, top view.
Source organism: Escherichia coli
Primary publication:
Rationally designed small compounds inhibit pilus biogenesis in uropathogenic bacteria.
Pinkner JS, Remaut H, Buelens F, Miller E, Aberg V, Pemberton N, Hedenström M, Larsson A, Seed P, Waksman G, Hultgren SJ, Almqvist F
Proc Natl Acad Sci U S A 103 17897-902 (2006)
PMID: 17098869

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147317 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Chaperone protein PapD Chain: A
Molecule details ›
Chain: A
Length: 218 amino acids
Theoretical weight: 24.58 KDa
Source organism: Escherichia coli
Expression system: Escherichia coli
UniProt:
  • Canonical: P15319 (Residues: 22-239; Coverage: 100%)
Gene name: papD
Sequence domains:
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
Ligand XC2 1 x XC2
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: ESRF BEAMLINE ID14-1
Spacegroup: P6322
Unit cell:
a: 94.315Å b: 94.315Å c: 121.992Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.232 0.232 0.273
Expression system: Escherichia coli

Quick links

Citations

73 review citations

Urinary tract infections: epidemiology, mechanisms of infection and treatment options.
Flores-Mireles et al. (2015)
72 more

2 mentions without citation

Rationally designed small compounds inhibit pilus biogenesis in uropathogenic bacteria.
Pinkner et al. (2006)
1 more