› 2j7z

X-ray diffraction
1.95Å resolution

Crystal Structure of recombinant Human Stromal Cell-Derived Factor- 1alpha

Released:
DOI: 10.2210/pdb2j7z/pdb
PDB entry 2j7z coloured by chain, front view.
PDB entry 2j7z coloured by chain, side view.
PDB entry 2j7z coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of recombinant human stromal cell-derived factor-1alpha.
Ryu EK, Kim TG, Kwon TH, Jung ID, Ryu D, Park YM, Kim J, Ahn KH, Ban C
Proteins 67 1193-7 (2007)
PMID: 17357154

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155706 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Stromal cell-derived factor 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 68 amino acids
Theoretical weight: 7.98 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P48061 (Residues: 22-89; Coverage: 94%)
Gene names: CXCL12, SDF1, SDF1A, SDF1B
Sequence domains: Small cytokines (intecrine/chemokine), interleukin-8 like
Structure domains: OB fold (Dihydrolipoamide Acetyltransferase, E2P)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PAL/PLS BEAMLINE 4A
Spacegroup: P212121
Unit cell:
a: 35.215Å b: 56.675Å c: 71.629Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.213 0.213 0.247
Expression system: Escherichia coli BL21(DE3)

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Citations

1 review citation

Targeting tumor micro-environment for design and development of novel anti-angiogenic agents arresting tumor growth.
Gacche et al. (2013)
13 other articles

13 mentions without citation

Chemokine oligomerization and interactions with receptors and glycosaminoglycans: the role of structural dynamics in function.
Salanga et al. (2011)
12 more