› 2j9l

X-ray diffraction
2.3Å resolution

Cytoplasmic Domain of the Human Chloride Transporter ClC-5 in complex with ATP

Released:
DOI: 10.2210/pdb2j9l/pdb
PDB entry 2j9l coloured by chain, front view.
PDB entry 2j9l coloured by chain, side view.
PDB entry 2j9l coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Nucleotide recognition by the cytoplasmic domain of the human chloride transporter ClC-5.
Meyer S, Savaresi S, Forster IC, Dutzler R
Nat Struct Mol Biol 14 60-7 (2007)
PMID: 17195847

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156417 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
H(+)/Cl(-) exchange transporter 5 Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 185 amino acids
Theoretical weight: 21.08 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P51795 (Residues: 641-816; Coverage: 22%)
Gene names: CLCK2, CLCN5
Sequence domains: CBS domain
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand ATP 6 x ATP
Ligand CL 10 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P21212
Unit cell:
a: 122.328Å b: 148.101Å c: 79.883Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.264 0.263 0.295
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

30 review citations

CLC chloride channels and transporters: from genes to protein structure, pathology and physiology.
Jentsch TJ. (2008)
29 more

18 mentions without citation

Ion channels in renal disease.
Kuo et al. (2012)
17 more