› 2jbh

X-ray diffraction
1.7Å resolution

Human phosphoribosyl transferase domain containing 1

Released:
DOI: 10.2210/pdb2jbh/pdb
PDB entry 2jbh coloured by chain, front view.
PDB entry 2jbh coloured by chain, side view.
PDB entry 2jbh coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural and functional studies of the human phosphoribosyltransferase domain containing protein 1.
Welin M, Egeblad L, Johansson A, Stenmark P, Wang L, Flodin S, Nyman T, Trésaugues L, Kotenyova T, Johansson I, Eriksson S, Eklund H, Nordlund P
FEBS J 277 4920-30 (2010)
PMID: 21054786

Function and Biology Details

Reaction catalysed: 
IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192558 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Phosphoribosyltransferase domain-containing protein 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 225 amino acids
Theoretical weight: 25.81 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9NRG1 (Residues: 1-225; Coverage: 100%)
Gene names: HHGP, PRTFDC1
Sequence domains: Phosphoribosyl transferase domain
Structure domains: Rossmann fold

Ligands and Environments

3 bound ligands:
Ligand PO4 2 x PO4
Ligand CA 4 x CA
Ligand 5GP 2 x 5GP
1 modified residue:
Ligand CAS 2 x CAS

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: P321
Unit cell:
a: 139.232Å b: 139.232Å c: 52.132Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.184 0.182 0.215
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

1 review citation

Pharmacogenetics and Pharmacotherapy of Military Personnel Suffering from Post-traumatic Stress Disorder.
Naß et al. (2017)
4 other articles

1 mention without citation

The dipeptidyl peptidase IV inhibitors vildagliptin and K-579 inhibit a phospholipase C: a case of promiscuous scaffolds in proteins.
Chakraborty et al. (2013)