› 2jbx

X-ray diffraction
2.73Å resolution

Crystal Structure of the myxoma virus anti-apoptotic protein M11L

Released:
DOI: 10.2210/pdb2jbx/pdb
PDB entry 2jbx coloured by chain, front view.
PDB entry 2jbx coloured by chain, side view.
PDB entry 2jbx coloured by chain, top view.
Source organism: Myxoma virus
Primary publication:
A structural viral mimic of prosurvival Bcl-2: a pivotal role for sequestering proapoptotic Bax and Bak.
Kvansakul M, van Delft MF, Lee EF, Gulbis JM, Fairlie WD, Huang DC, Colman PM
Mol Cell 25 933-42 (2007)
PMID: 17386268

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-183085 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Apoptosis regulator M11L Chains: A, B
Molecule details ›
Chains: A, B
Length: 145 amino acids
Theoretical weight: 16.88 KDa
Source organism: Myxoma virus
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q85295 (Residues: 1-132; Coverage: 80%)
Gene names: M11L, m011L
Sequence domains: Apoptosis regulator M11L like
Structure domains: Blc2-like

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 12 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007
Spacegroup: P1
Unit cell:
a: 39.876Å b: 39.398Å c: 49.222Å
α: 71.79° β: 90.09° γ: 81.66°
R-values:
R R work R free
0.218 0.214 0.286
Expression system: Escherichia coli BL21

Quick links

Citations

29 review citations

The BCL-2 protein family: opposing activities that mediate cell death.
Youle et al. (2008)
28 more

5 mentions without citation

The Bcl-2 Family: Ancient Origins, Conserved Structures, and Divergent Mechanisms.
Banjara et al. (2020)
4 more