› 2jhe

X-ray diffraction
2.3Å resolution

N-terminal domain of TyrR transcription factor (residues 1 - 190)

Released:
DOI: 10.2210/pdb2jhe/pdb
PDB entry 2jhe coloured by chain, front view.
PDB entry 2jhe coloured by chain, side view.
PDB entry 2jhe coloured by chain, top view.
Source organism: Escherichia coli K-12
Primary publication:
Crystal structure of the N-terminal domain of the TyrR transcription factor responsible for gene regulation of aromatic amino acid biosynthesis and transport in Escherichia coli K12.
Verger D, Carr PD, Kwok T, Ollis DL
J Mol Biol 367 102-12 (2007)
PMID: 17222426

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139659 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
HTH-type transcriptional regulatory protein TyrR Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 190 amino acids
Theoretical weight: 21.72 KDa
Source organism: Escherichia coli K-12
Expression system: Escherichia coli K-12
UniProt:
  • Canonical: P07604 (Residues: 1-190; Coverage: 37%)
Gene names: JW1316, b1323, tyrR
Sequence domains: PAS domain
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand AE3 1 x AE3
Ligand PG4 2 x PG4
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE BM14
Spacegroup: C2
Unit cell:
a: 134.456Å b: 72.009Å c: 96.814Å
α: 90° β: 98.46° γ: 90°
R-values:
R R work R free
0.252 0.248 0.317
Expression system: Escherichia coli K-12

Quick links

Citations

1 review citation

The role of bacterial enhancer binding proteins as specialized activators of σ54-dependent transcription.
Bush et al. (2012)
5 other articles

6 mentions without citation

Structure and signaling mechanism of Per-ARNT-Sim domains.
Möglich et al. (2009)
5 more