› 2jhr

X-ray diffraction
2.8Å resolution

Crystal structure of myosin-2 motor domain in complex with ADP- metavanadate and pentabromopseudilin

Released:
DOI: 10.2210/pdb2jhr/pdb
PDB entry 2jhr coloured by chain, front view.
PDB entry 2jhr coloured by chain, side view.
PDB entry 2jhr coloured by chain, top view.
Source organism: Dictyostelium discoideum
Primary publication:
The mechanism of pentabromopseudilin inhibition of myosin motor activity.
Fedorov R, Böhl M, Tsiavaliaris G, Hartmann FK, Taft MH, Baruch P, Brenner B, Martin R, Knölker HJ, Gutzeit HO, Manstein DJ
Nat Struct Mol Biol 16 80-8 (2009)
PMID: 19122661

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140379 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Myosin-2 heavy chain Chain: A
Molecule details ›
Chain: A
Length: 788 amino acids
Theoretical weight: 90.01 KDa
Source organism: Dictyostelium discoideum
UniProt:
  • Canonical: P08799 (Residues: 2-761; Coverage: 36%)
Gene names: DDB_G0286355, mhcA
Sequence domains:

Ligands and Environments

3 bound ligands:
Ligand AD9 1 x AD9
Ligand MG 1 x MG
Ligand PBQ 1 x PBQ
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BRUKER AXS MICROSTAR
Spacegroup: C2221
Unit cell:
a: 89.758Å b: 150.464Å c: 154.55Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.217 0.217 0.265

Quick links

Citations

6 review citations

Nonmuscle myosin-2: mix and match.
Heissler et al. (2013)
5 more

10 mentions without citation

Poorly understood aspects of striated muscle contraction.
Månsson et al. (2015)
9 more