› 2jk4

X-ray diffraction
4.1Å resolution

Structure of the human voltage-dependent anion channel

Released:
DOI: 10.2210/pdb2jk4/pdb
PDB entry 2jk4 coloured by chain, front view.
PDB entry 2jk4 coloured by chain, side view.
PDB entry 2jk4 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the human voltage-dependent anion channel.
Bayrhuber M, Meins T, Habeck M, Becker S, Giller K, Villinger S, Vonrhein C, Griesinger C, Zweckstetter M, Zeth K
Proc Natl Acad Sci U S A 105 15370-5 (2008)
PMID: 18832158

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149424 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Voltage-dependent anion-selective channel protein 1 Chain: A
Molecule details ›
Chain: A
Length: 294 amino acids
Theoretical weight: 32.18 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P21796 (Residues: 2-283; Coverage: 100%)
Gene names: VDAC, VDAC1
Sequence domains: Eukaryotic porin

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: P3221
Unit cell:
a: 77.99Å b: 77.99Å c: 167.04Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.331 0.325 0.387
Expression system: Escherichia coli

Quick links

Citations

95 review citations

VDAC, a multi-functional mitochondrial protein regulating cell life and death.
Shoshan-Barmatz et al. (2010)
94 more

48 mentions without citation

The structural biology of β-barrel membrane proteins: a summary of recent reports.
Fairman et al. (2011)
47 more