› 2jrz

Solution NMR

Solution structure of the Bright/ARID domain from the human JARID1C protein.

Released:
DOI: 10.2210/pdb2jrz/pdb
PDB entry 2jrz coloured by chain, ensemble of 20 models, front view.
PDB entry 2jrz coloured by chain, ensemble of 20 models, side view.
PDB entry 2jrz coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Backbone and sidechain 1H, 13C and 15N resonance assignments of the Bright/ARID domain from the human JARID1C (SMCX) protein.
Koehler C, Bishop S, Dowler EF, Schmieder P, Diehl A, Oschkinat H, Ball LJ
Biomol NMR Assign 2 9-11 (2008)
PMID: 19636912

Function and Biology Details

Reaction catalysed: 
(1a) a [histone H3]-N(6),N(6),N(6)-trimethyl-L-lysine(4) + 2-oxoglutarate + O(2) = a [histone H3]-N(6),N(6)-dimethyl-L-lysine(4) + succinate + formaldehyde + CO(2)
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154348 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Lysine-specific demethylase 5C Chain: A
Molecule details ›
Chain: A
Length: 117 amino acids
Theoretical weight: 13.75 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P41229 (Residues: 73-188; Coverage: 7%)
Gene names: DXS1272E, JARID1C, KDM5C, SMCX, XE169
Sequence domains: ARID/BRIGHT DNA binding domain
Structure domains: ARID DNA-binding domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 82%
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

3 review citations

Inhibitors of histone demethylases.
Lohse et al. (2011)
2 more

9 mentions without citation

The scientific impact of the Structural Genomics Consortium: a protein family and ligand-centered approach to medically-relevant human proteins.
Gileadi et al. (2007)
8 more