› 2jsq

Solution NMR

Monomeric Human Telomere DNA Tetraplex with 3+1 Strand Fold Topology, Two Edgewise Loops and Double-Chain Reversal Loop, Form 2 15BrG, NMR, 10 Structures

Released:
DOI: 10.2210/pdb2jsq/pdb
PDB entry 2jsq coloured by chain, ensemble of 10 models, front view.
PDB entry 2jsq coloured by chain, ensemble of 10 models, side view.
PDB entry 2jsq coloured by chain, ensemble of 10 models, top view.
Source organism: Synthetic construct
Primary publication:
Structure of two intramolecular G-quadruplexes formed by natural human telomere sequences in K+ solution.
Phan AT, Kuryavyi V, Luu KN, Patel DJ
Nucleic Acids Res 35 6517-25 (2007)
PMID: 17895279

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-115436 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
HUMAN TELOMERE DNA Chain: A
Molecule details ›
Chain: A
Length: 25 nucleotides
Theoretical weight: 7.97 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands
1 modified residue:
Ligand BGM 1 x BGM

Experiments and Validation Details

Entry percentile scores
Refinement method: TORSION ANGLE DYNAMICS CARTESIAN DYNAMICS MATRIX RELAXATION
Expression system: Not provided

Quick links

Citations

37 review citations

Stability and kinetics of G-quadruplex structures.
Lane et al. (2008)
36 more

10 mentions without citation

Human telomere, oncogenic promoter and 5'-UTR G-quadruplexes: diverse higher order DNA and RNA targets for cancer therapeutics.
Patel et al. (2007)
9 more