› 2jt7

Solution NMR

NMR solution structure of the 4:1 distamycin A/[d(TGGGGT)]4 complex

Released:
DOI: 10.2210/pdb2jt7/pdb
PDB entry 2jt7 coloured by chain, ensemble of 10 models, front view.
PDB entry 2jt7 coloured by chain, ensemble of 10 models, side view.
PDB entry 2jt7 coloured by chain, ensemble of 10 models, top view.
Source organism: Synthetic construct
Primary publication:
Structural and thermodynamic studies of the interaction of distamycin A with the parallel quadruplex structure [d(TGGGGT)]4.
Martino L, Virno A, Pagano B, Virgilio A, Di Micco S, Galeone A, Giancola C, Bifulco G, Mayol L, Randazzo A
J Am Chem Soc 129 16048-56 (2007)
PMID: 18052170

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-115437 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
DNA (5'-D(*DTP*DGP*DGP*DGP*DGP*DT)-3') Chains: A, B, E, F
Molecule details ›
Chains: A, B, E, F
Length: 6 nucleotides
Theoretical weight: 1.88 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand DMY 4 x DMY
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Not provided

Quick links

Citations

13 review citations

Human telomeric G-quadruplex: structures of DNA and RNA sequences.
Phan AT. (2010)
12 more

8 mentions without citation

Structure-based DNA-targeting strategies with small molecule ligands for drug discovery.
Sheng et al. (2013)
7 more