› 2jtg

Solution NMR

Solution structure of the THAP-zinc finger of THAP1

Released:
DOI: 10.2210/pdb2jtg/pdb
PDB entry 2jtg coloured by chain, ensemble of 20 models, front view.
PDB entry 2jtg coloured by chain, ensemble of 20 models, side view.
PDB entry 2jtg coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Structure-function analysis of the THAP zinc finger of THAP1, a large C2CH DNA-binding module linked to Rb/E2F pathways.
Bessière D, Lacroix C, Campagne S, Ecochard V, Guillet V, Mourey L, Lopez F, Czaplicki J, Demange P, Milon A, Girard JP, Gervais V
J Biol Chem 283 4352-63 (2008)
PMID: 18073205

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192643 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
THAP domain-containing protein 1 Chain: A
Molecule details ›
Chain: A
Length: 87 amino acids
Theoretical weight: 10.22 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9NVV9 (Residues: 1-81; Coverage: 38%)
Gene name: THAP1
Sequence domains: THAP domain

Ligands and Environments

1 bound ligand:
Ligand ZN 1 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

11 review citations

Dystonia.
Balint et al. (2018)
10 more

2 mentions without citation

Structural determinants of specific DNA-recognition by the THAP zinc finger.
Campagne et al. (2010)
1 more