› 2jwo

Solution NMR

A PHD finger motif in the C-terminus of RAG2 modulates recombination activity

Released:
DOI: 10.2210/pdb2jwo/pdb
PDB entry 2jwo coloured by chain, ensemble of 20 models, front view.
PDB entry 2jwo coloured by chain, ensemble of 20 models, side view.
PDB entry 2jwo coloured by chain, ensemble of 20 models, top view.
Source organism: Mus musculus
Primary publication:
A PHD finger motif in the C terminus of RAG2 modulates recombination activity.
Elkin SK, Ivanov D, Ewalt M, Ferguson CG, Hyberts SG, Sun ZY, Prestwich GD, Yuan J, Wagner G, Oettinger MA, Gozani OP
J Biol Chem 280 28701-10 (2005)
PMID: 15964836

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149418 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
V(D)J recombination-activating protein 2 Chain: A
Molecule details ›
Chain: A
Length: 82 amino acids
Theoretical weight: 9.36 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P21784 (Residues: 414-487; Coverage: 14%)
Gene names: Rag-2, Rag2
Sequence domains: RAG2 PHD domain
Structure domains: Rag2 PHD finger

Ligands and Environments

1 bound ligand:
Ligand ZN 2 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli BL21

Quick links

Citations

20 review citations

Mechanism and control of V(D)J recombination at the immunoglobulin heavy chain locus.
Jung et al. (2006)
19 more

1 mention without citation

Insights into RAG Evolution from the Identification of "Missing Link" Family A RAGL Transposons.
Martin et al. (2023)