› 2jx4

Solution NMR

NMR structure of the intracellular loop (i3) of the vasopressin V2 receptor (GPCR)

Released:
DOI: 10.2210/pdb2jx4/pdb
PDB entry 2jx4 coloured by chain, ensemble of 20 models, front view.
PDB entry 2jx4 coloured by chain, ensemble of 20 models, side view.
PDB entry 2jx4 coloured by chain, ensemble of 20 models, top view.
Source organism: Rattus norvegicus
Primary publication:
Structure of the third intracellular loop of the vasopressin V2 receptor and conformational changes upon binding to gC1qR.
Bellot G, Granier S, Bourguet W, Seyer R, Rahmeh R, Mouillac B, Pascal R, Mendre C, Déméné H
J Mol Biol 388 491-507 (2009)
PMID: 19285506

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-169472 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Vasopressin V2 receptor Chain: A
Molecule details ›
Chain: A
Length: 52 amino acids
Theoretical weight: 5.53 KDa
Source organism: Rattus norvegicus
Expression system: Not provided
UniProt:
  • Canonical: Q00788 (Residues: 225-273; Coverage: 13%)
Gene name: Avpr2
Structure domains: Helix Hairpins

Ligands and Environments

No bound ligands
3 modified residues:
Ligand DGN 1 x DGN
Ligand NLE 2 x NLE
Ligand CCS 1 x CCS

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics
Expression system: Not provided

Quick links

Citations

4 review citations

Relevance of rhodopsin studies for GPCR activation.
Deupi X. (2014)
3 more