› 2jxd

Solution NMR

NMR structure of human Serine protease inhibitor Kazal type II (SPINK2)

Released:
DOI: 10.2210/pdb2jxd/pdb
PDB entry 2jxd coloured by chain, ensemble of 15 models, front view.
PDB entry 2jxd coloured by chain, ensemble of 15 models, side view.
PDB entry 2jxd coloured by chain, ensemble of 15 models, top view.
Source organism: Homo sapiens
Primary publication:
Identification of trypsin-inhibitory site and structure determination of human SPINK2 serine proteinase inhibitor.
Chen T, Lee TR, Liang WG, Chang WS, Lyu PC
Proteins 77 209-19 (2009)
PMID: 19422058

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148863 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine protease inhibitor Kazal-type 2 Chain: A
Molecule details ›
Chain: A
Length: 62 amino acids
Theoretical weight: 7.02 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P20155 (Residues: 23-84; Coverage: 100%)
Gene name: SPINK2
Sequence domains: Kazal-type serine protease inhibitor domain
Structure domains: Wheat Germ Agglutinin (Isolectin 2); domain 1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing, Water refinement
Expression system: Escherichia coli

Quick links

Citations

1 review citation

SPINKs in Tumors: Potential Therapeutic Targets.
Liao et al. (2022)
12 other articles

4 mentions without citation

The solution structure of the kallikrein-related peptidases inhibitor SPINK6.
Jung et al. (2016)
3 more