› 2jxo

Solution NMR

Structure of the second PDZ domain of NHERF-1

Released:
DOI: 10.2210/pdb2jxo/pdb
PDB entry 2jxo coloured by chain, ensemble of 12 models, front view.
PDB entry 2jxo coloured by chain, ensemble of 12 models, side view.
PDB entry 2jxo coloured by chain, ensemble of 12 models, top view.
Source organism: Homo sapiens
Primary publication:
Autoinhibitory interactions between the PDZ2 and C-terminal domains in the scaffolding protein NHERF1.
Cheng H, Li J, Fazlieva R, Dai Z, Bu Z, Roder H
Structure 17 660-9 (2009)
PMID: 19446522

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127084 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Na(+)/H(+) exchange regulatory cofactor NHE-RF1 Chain: A
Molecule details ›
Chain: A
Length: 98 amino acids
Theoretical weight: 10.73 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O14745 (Residues: 150-240; Coverage: 25%)
Gene names: NHERF, NHERF1, SLC9A3R1
Sequence domains: PDZ domain
Structure domains: Pdz3 Domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: DGSA-distance geometry simulated annealing
Expression system: Escherichia coli

Quick links

Citations

10 review citations

Organizing the cell cortex: the role of ERM proteins.
Fehon et al. (2010)
9 more

2 mentions without citation

A conformational switch in the scaffolding protein NHERF1 controls autoinhibition and complex formation.
Bhattacharya et al. (2010)
1 more