› 2k1v

Solution NMR

R3/I5 relaxin chimera

Released:
DOI: 10.2210/pdb2k1v/pdb
PDB entry 2k1v coloured by chain, ensemble of 20 models, front view.
PDB entry 2k1v coloured by chain, ensemble of 20 models, side view.
PDB entry 2k1v coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the R3/I5 chimeric relaxin peptide, a selective GPCR135 and GPCR142 agonist.
Haugaard-Jönsson LM, Hossain MA, Daly NL, Bathgate RA, Wade JD, Craik DJ, Rosengren KJ
J Biol Chem 283 23811-8 (2008)
PMID: 18577524

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-186777 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Relaxin-3 B chain Chain: B
Molecule details ›
Chain: B
Length: 27 amino acids
Theoretical weight: 3.05 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q8WXF3 (Residues: 26-52; Coverage: 23%)
Gene names: INSL7, RLN3, RXN3, UNQ6188/PRO20213, ZINS4
Insulin-like peptide INSL5 A chain Chain: A
Molecule details ›
Chain: A
Length: 22 amino acids
Theoretical weight: 2.2 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q9Y5Q6 (Residues: 115-135; Coverage: 19%)
Gene names: INSL5, UNQ156/PRO182

Ligands and Environments

No bound ligands
1 modified residue:
Ligand PCA 1 x PCA

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Not provided

Quick links

Citations

6 review citations

Relaxin family peptides and their receptors.
Bathgate et al. (2013)
5 more

3 mentions without citation

Structure of the R3/I5 chimeric relaxin peptide, a selective GPCR135 and GPCR142 agonist.
Haugaard-Jönsson et al. (2008)
2 more