› 2k2f

Solution NMR

Solution structure of Ca2+-S100A1-RyRP12

Released:
DOI: 10.2210/pdb2k2f/pdb
PDB entry 2k2f coloured by chain, ensemble of 20 models, front view.
PDB entry 2k2f coloured by chain, ensemble of 20 models, side view.
PDB entry 2k2f coloured by chain, ensemble of 20 models, top view.
Source organism: Rattus norvegicus
Primary publication:
S100A1 and calmodulin compete for the same binding site on ryanodine receptor.
Wright NT, Prosser BL, Varney KM, Zimmer DB, Schneider MF, Weber DJ
J Biol Chem 283 26676-83 (2008)
PMID: 18650434

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-109179 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Ryanodine receptor 2 Chains: C, D
Molecule details ›
Chains: C, D
Length: 12 amino acids
Theoretical weight: 1.47 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: B0LPN4 (Residues: 3561-3572; Coverage: 0%)
Gene name: Ryr2
Protein S100-A1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 93 amino acids
Theoretical weight: 10.44 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: P35467 (Residues: 2-94; Coverage: 99%)
Gene name: S100a1
Sequence domains:
Structure domains: EF-hand

Ligands and Environments

1 bound ligand:
Ligand CA 4 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: DGSA-distance geometry simulated annealing
Expression system: Escherichia coli

Quick links

Citations

19 review citations

Functions of S100 proteins.
Donato et al. (2013)
18 more

9 mentions without citation

Critical Role of Intracellular RyR1 Calcium Release Channels in Skeletal Muscle Function and Disease.
Hernández-Ochoa et al. (2015)
8 more