› 2k2o

Solution NMR

Solution Structure of the inner DysF domain of human myoferlin

Released:
DOI: 10.2210/pdb2k2o/pdb
PDB entry 2k2o coloured by chain, ensemble of 20 models, front view.
PDB entry 2k2o coloured by chain, ensemble of 20 models, side view.
PDB entry 2k2o coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Solution structure of the inner DysF domain of myoferlin and implications for limb girdle muscular dystrophy type 2b.
Patel P, Harris R, Geddes SM, Strehle EM, Watson JD, Bashir R, Bushby K, Driscoll PC, Keep NH
J Mol Biol 379 981-90 (2008)
PMID: 18495154

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192765 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Myoferlin Chain: A
Molecule details ›
Chain: A
Length: 123 amino acids
Theoretical weight: 14.2 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q9NZM1 (Residues: 923-1040; Coverage: 6%)
Gene names: FER1L3, KIAA1207, MYOF

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 90%
Refinement method: molecular dynamics
Expression system: Escherichia coli BL21

Quick links

Citations

10 review citations

Ferlins: regulators of vesicle fusion for auditory neurotransmission, receptor trafficking and membrane repair.
Lek et al. (2012)
9 more

4 mentions without citation

Crystal structures of the human Dysferlin inner DysF domain.
Sula et al. (2014)
3 more