› 2k3h

Solution NMR

Structural determinants for Ca2+ and PIP2 binding by the C2A domain of rabphilin-3A

Released:
DOI: 10.2210/pdb2k3h/pdb
PDB entry 2k3h coloured by chain, ensemble of 20 models, front view.
PDB entry 2k3h coloured by chain, ensemble of 20 models, side view.
PDB entry 2k3h coloured by chain, ensemble of 20 models, top view.
Source organism: Mus musculus
Primary publication:
Structural determinants for Ca2+ and phosphatidylinositol 4,5-bisphosphate binding by the C2A domain of rabphilin-3A.
Coudevylle N, Montaville P, Leonov A, Zweckstetter M, Becker S
J Biol Chem 283 35918-28 (2008)
PMID: 18945677

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155636 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Rabphilin-3A Chain: A
Molecule details ›
Chain: A
Length: 140 amino acids
Theoretical weight: 16.07 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P47708 (Residues: 368-507; Coverage: 21%)
Gene name: Rph3a
Sequence domains: C2 domain
Structure domains: C2 domain

Ligands and Environments

1 bound ligand:
Ligand CA 2 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

5 review citations

Signaling through C2 domains: more than one lipid target.
Corbalan-Garcia et al. (2014)
4 more

5 mentions without citation

Structural insights into the Ca2+ and PI(4,5)P2 binding modes of the C2 domains of rabphilin 3A and synaptotagmin 1.
Guillén et al. (2013)
4 more