› 2k3j

Solution NMR

The solution structure of human Mia40

Released:
DOI: 10.2210/pdb2k3j/pdb
PDB entry 2k3j coloured by chain, ensemble of 20 models, front view.
PDB entry 2k3j coloured by chain, ensemble of 20 models, side view.
PDB entry 2k3j coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
MIA40 is an oxidoreductase that catalyzes oxidative protein folding in mitochondria.
Banci L, Bertini I, Cefaro C, Ciofi-Baffoni S, Gallo A, Martinelli M, Sideris DP, Katrakili N, Tokatlidis K
Nat Struct Mol Biol 16 198-206 (2009)
PMID: 19182799

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-185394 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mitochondrial intermembrane space import and assembly protein 40 Chain: A
Molecule details ›
Chain: A
Length: 146 amino acids
Theoretical weight: 16.4 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8N4Q1 (Residues: 1-142; Coverage: 100%)
Gene names: CHCHD4, MIA40
Sequence domains: CHCH domain
Structure domains: Helix Hairpins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 84%
Refinement method: molecular dynamics
Expression system: Escherichia coli

Quick links

Citations

69 review citations

Importing mitochondrial proteins: machineries and mechanisms.
Chacinska et al. (2009)
68 more

12 mentions without citation

Chemistry and Enzymology of Disulfide Cross-Linking in Proteins.
Fass et al. (2018)
11 more