› 2k3w

Solution NMR

Function and Biology Details

Reaction catalysed: 
ATP + H(2)O = ADP + phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-188511 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Vacuolar protein sorting-associated protein 4A Chain: A
Molecule details ›
Chain: A
Length: 84 amino acids
Theoretical weight: 9.87 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9UN37 (Residues: 1-84; Coverage: 19%)
Gene names: VPS4, VPS4A
Sequence domains: MIT (microtubule interacting and transport) domain
Structure domains: Phosphotransferase system, lactose/cellobiose-type IIA subunit
Charged multivesicular body protein 6 Chain: B
Molecule details ›
Chain: B
Length: 16 amino acids
Theoretical weight: 1.84 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q96FZ7 (Residues: 166-181; Coverage: 8%)
Gene names: CHMP6, VPS20

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

36 review citations

Membrane budding and scission by the ESCRT machinery: it's all in the neck.
Hurley et al. (2010)
35 more

9 mentions without citation

The ESCRT complexes.
Hurley JH. (2010)
8 more