› 2k60

Solution NMR

NMR structure of calcium-loaded STIM1 EF-SAM

Released:
DOI: 10.2210/pdb2k60/pdb
PDB entry 2k60 coloured by chain, ensemble of 20 models, front view.
PDB entry 2k60 coloured by chain, ensemble of 20 models, side view.
PDB entry 2k60 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Structural and mechanistic insights into STIM1-mediated initiation of store-operated calcium entry.
Stathopulos PB, Zheng L, Li GY, Plevin MJ, Ikura M
Cell 135 110-22 (2008)
PMID: 18854159

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171769 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Stromal interaction molecule 1 Chain: A
Molecule details ›
Chain: A
Length: 150 amino acids
Theoretical weight: 17.38 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q13586 (Residues: 58-201; Coverage: 22%)
Gene names: GOK, STIM1
Sequence domains: SAM domain (Sterile alpha motif)
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand CA 1 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing, simulated annealing
Expression system: Escherichia coli

Quick links

Citations

114 review citations

Molecular basis of calcium signaling in lymphocytes: STIM and ORAI.
Hogan et al. (2010)
113 more

18 mentions without citation

Store-Operated Calcium Channels.
Prakriya et al. (2015)
17 more