› 2k7e

Solution NMR

NMR structure of the human tRNALys3 bound to the HIV genome Loop I

Released:
DOI: 10.2210/pdb2k7e/pdb
PDB entry 2k7e coloured by chain, ensemble of 10 models, front view.
PDB entry 2k7e coloured by chain, ensemble of 10 models, side view.
PDB entry 2k7e coloured by chain, ensemble of 10 models, top view.
Source organism: Synthetic construct
Primary publication:
The structure of the human tRNALys3 anticodon bound to the HIV genome is stabilized by modified nucleosides and adjacent mismatch base pairs.
Bilbille Y, Vendeix FA, Guenther R, Malkiewicz A, Ariza X, Vilarrasa J, Agris PF
Nucleic Acids Res 37 3342-53 (2009)
PMID: 19324888

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-196412 (preferred)
Entry contents:
2 distinct RNA molecules
Macromolecules (2 distinct):
RNA (5'-R(*GP*CP*GP*GP*UP*GP*UP*AP*AP*AP*AP*G)-3') Chain: A
Molecule details ›
Chain: A
Length: 12 nucleotides
Theoretical weight: 3.92 KDa
Source organism: Synthetic construct
Expression system: Not provided
RNA (5'-R(*CP*UP*(SUR)P*UP*UP*AP*AP*(PSU)P*CP*UP*GP*C)-3') Chain: B
Molecule details ›
Chain: B
Length: 12 nucleotides
Theoretical weight: 3.73 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands
2 modified residues:
Ligand SUR 1 x SUR
Ligand PSU 1 x PSU

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Not provided

Quick links

Citations

11 review citations

Transfer RNA modifications: nature's combinatorial chemistry playground.
Jackman et al. (2013)
10 more

6 mentions without citation

Structural and computational studies of HIV-1 RNA.
Levintov et al. (2024)
5 more