› 2k8v

Solution NMR

Solution structure of Oxidised ERp18

Released:
DOI: 10.2210/pdb2k8v/pdb
PDB entry 2k8v coloured by chain, ensemble of 40 models, front view.
PDB entry 2k8v coloured by chain, ensemble of 40 models, side view.
PDB entry 2k8v coloured by chain, ensemble of 40 models, top view.
Source organism: Homo sapiens
Primary publication:
Solution structure and dynamics of ERp18, a small endoplasmic reticulum resident oxidoreductase .
Rowe ML, Ruddock LW, Kelly G, Schmidt JM, Williamson RA, Howard MJ
Biochemistry 48 4596-606 (2009)
PMID: 19361226

Function and Biology Details

Reaction catalysed: 
2 glutathione + protein-disulfide = glutathione disulfide + protein-dithiol
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132079 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Thioredoxin domain-containing protein 12 Chain: A
Molecule details ›
Chain: A
Length: 157 amino acids
Theoretical weight: 17.8 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O95881 (Residues: 24-172; Coverage: 100%)
Gene names: TLP19, TXNDC12, UNQ713/PRO1376
Sequence domains: Thioredoxin-like
Structure domains: Glutaredoxin

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

6 review citations

Protein folding and modification in the mammalian endoplasmic reticulum.
Braakman et al. (2011)
5 more

3 mentions without citation

Functions and mechanisms of protein disulfide isomerase family in cancer emergence.
Rahman et al. (2022)
2 more