› 2kd3

Solution NMR

NMR structure of the Wnt modulator protein Sclerostin

Released:
DOI: 10.2210/pdb2kd3/pdb
PDB entry 2kd3 coloured by chain, ensemble of 15 models, front view.
PDB entry 2kd3 coloured by chain, ensemble of 15 models, side view.
PDB entry 2kd3 coloured by chain, ensemble of 15 models, top view.
Source organism: Mus musculus
Primary publication:
NMR structure of the Wnt modulator protein Sclerostin.
Weidauer SE, Schmieder P, Beerbaum M, Schmitz W, Oschkinat H, Mueller TD
Biochem Biophys Res Commun 380 160-5 (2009)
PMID: 19166819

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189367 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sclerostin Chain: A
Molecule details ›
Chain: A
Length: 113 amino acids
Theoretical weight: 12.71 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q99P68 (Residues: 59-167; Coverage: 58%)
Gene name: Sost
Sequence domains: Sclerostin (SOST)
Structure domains: Cystine-knot cytokines

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli

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Citations

17 review citations

WNT signaling in bone homeostasis and disease: from human mutations to treatments.
Baron et al. (2013)
16 more

3 mentions without citation

Structural Biology and Evolution of the TGF-β Family.
Hinck et al. (2016)
2 more