› 2ke1

Solution NMR

Molecular Basis of non-modified histone H3 tail Recognition by the First PHD Finger of Autoimmune Regulator

Released:
DOI: 10.2210/pdb2ke1/pdb
PDB entry 2ke1 coloured by chain, ensemble of 20 models, front view.
PDB entry 2ke1 coloured by chain, ensemble of 20 models, side view.
PDB entry 2ke1 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
The solution structure of the first PHD finger of autoimmune regulator in complex with non-modified histone H3 tail reveals the antagonistic role of H3R2 methylation.
Chignola F, Gaetani M, Rebane A, Org T, Mollica L, Zucchelli C, Spitaleri A, Mannella V, Peterson P, Musco G
Nucleic Acids Res 37 2951-61 (2009)
PMID: 19293276

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-129168 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Autoimmune regulator Chain: A
Molecule details ›
Chain: A
Length: 66 amino acids
Theoretical weight: 7.15 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O43918 (Residues: 293-354; Coverage: 11%)
Gene names: AIRE, APECED
Sequence domains: PHD-finger
Structure domains: Zinc/RING finger domain, C3HC4 (zinc finger)
H3K4me0 Chain: B
Molecule details ›
Chain: B
Length: 10 amino acids
Theoretical weight: 1.15 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand ZN 2 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

25 review citations

Perceiving the epigenetic landscape through histone readers.
Musselman et al. (2012)
24 more

13 mentions without citation

The PHD finger: a versatile epigenome reader.
Sanchez et al. (2011)
12 more