› 2kef

Solution NMR

Solution NMR structures of human hepcidin at 325K

Released:
DOI: 10.2210/pdb2kef/pdb
PDB entry 2kef coloured by chain, ensemble of 20 models, front view.
PDB entry 2kef coloured by chain, ensemble of 20 models, side view.
PDB entry 2kef coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Hepcidin revisited, disulfide connectivity, dynamics, and structure.
Jordan JB, Poppe L, Haniu M, Arvedson T, Syed R, Li V, Kohno H, Kim H, Schnier PD, Harvey TS, Miranda LP, Cheetham J, Sasu BJ
J Biol Chem 284 24155-67 (2009)
PMID: 19553669

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-160483 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Hepcidin-25 Chain: A
Molecule details ›
Chain: A
Length: 25 amino acids
Theoretical weight: 2.8 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P81172 (Residues: 60-84; Coverage: 42%)
Gene names: HAMP, HEPC, LEAP1, UNQ487/PRO1003
Sequence domains: Hepcidin

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics
Expression system: Cricetulus griseus

Quick links

Citations

25 review citations

Two to tango: regulation of Mammalian iron metabolism.
Hentze et al. (2010)
24 more

11 mentions without citation

Hepcidin Therapeutics.
Katsarou et al. (2018)
10 more