› 2ker

Solution NMR

alpha-amylase inhibitor Parvulustat (Z-2685) from Streptomyces parvulus

Released:
DOI: 10.2210/pdb2ker/pdb
PDB entry 2ker coloured by chain, ensemble of 20 models, front view.
PDB entry 2ker coloured by chain, ensemble of 20 models, side view.
PDB entry 2ker coloured by chain, ensemble of 20 models, top view.
Source organism: Streptomyces parvulus
Primary publication:
The high resolution NMR structure of parvulustat (Z-2685) from Streptomyces parvulus FH-1641: comparison with tendamistat from Streptomyces tendae 4158.
Rehm S, Han S, Hassani I, Sokocevic A, Jonker HR, Engels JW, Schwalbe H
Chembiochem 10 119-27 (2009)
PMID: 19067455

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139607 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Alpha-amylase inhibitor Z-2685 Chain: A
Molecule details ›
Chain: A
Length: 78 amino acids
Theoretical weight: 8.29 KDa
Source organism: Streptomyces parvulus
Expression system: Streptomyces lividans
UniProt:
  • Canonical: P07512 (Residues: 1-76; Coverage: 100%)
Sequence domains: Alpha amylase inhibitor
Structure domains: Alpha-amylase inhibitor

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing, torsion angle dynamics
Expression system: Streptomyces lividans

Quick links

Citations

2 review citations

Natural Inhibitors of Mammalian α-Amylases as Promising Drugs for the Treatment of Metabolic Diseases.
Kalinovskii et al. (2023)
1 more