› 2kes

Solution NMR

Solution Structure of the Coiled-coil Domain of Synphilin-1

Released:
DOI: 10.2210/pdb2kes/pdb
PDB entry 2kes coloured by chain, ensemble of 15 models, front view.
PDB entry 2kes coloured by chain, ensemble of 15 models, side view.
PDB entry 2kes coloured by chain, ensemble of 15 models, top view.
Source organism: Homo sapiens
Primary publication:
Interaction with synphilin-1 promotes inclusion formation of alpha-synuclein: mechanistic insights and pathological implication.
Xie YY, Zhou CJ, Zhou ZR, Hong J, Che MX, Fu QS, Song AX, Lin DH, Hu HY
FASEB J 24 196-205 (2010)
PMID: 19762560

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195363 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Synphilin-1 Chain: A
Molecule details ›
Chain: A
Length: 48 amino acids
Theoretical weight: 5.37 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9Y6H5 (Residues: 512-557; Coverage: 5%)
Gene name: SNCAIP
Sequence domains: Synphilin-1 alpha-Synuclein-binding domain
Structure domains: Single alpha-helices involved in coiled-coils or other helix-helix interfaces

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics
Expression system: Escherichia coli

Quick links

Citations

5 review citations

Basic mechanisms of neurodegeneration: a critical update.
Jellinger KA. (2010)
4 more

3 mentions without citation

The Parkinson Disease gene SNCA: Evolutionary and structural insights with pathological implication.
Siddiqui et al. (2016)
2 more