› 2kfx

Solution NMR

Structure of the N-terminal domain of human cardiac troponin C bound to calcium ion and to the inhibitor W7

Released:
DOI: 10.2210/pdb2kfx/pdb
PDB entry 2kfx coloured by chain, ensemble of 10 models, front view.
PDB entry 2kfx coloured by chain, ensemble of 10 models, side view.
PDB entry 2kfx coloured by chain, ensemble of 10 models, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the inhibitor W7 bound to the regulatory domain of cardiac troponin C.
Hoffman RM, Sykes BD
Biochemistry 48 5541-52 (2009)
PMID: 19419198

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-159088 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Troponin C, slow skeletal and cardiac muscles Chain: T
Molecule details ›
Chain: T
Length: 89 amino acids
Theoretical weight: 10.04 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P63316 (Residues: 1-89; Coverage: 55%)
Gene names: TNNC, TNNC1
Sequence domains: EF-hand domain pair

Ligands and Environments

2 bound ligands:
Ligand CA 1 x CA
Ligand WW7 1 x WW7
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: molecular dynamics
Expression system: Escherichia coli

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Citations

1 review citation

Cardiac Troponin and Tropomyosin: Structural and Cellular Perspectives to Unveil the Hypertrophic Cardiomyopathy Phenotype.
Marques et al. (2016)
8 other articles

7 mentions without citation

A structural and functional perspective into the mechanism of Ca2+-sensitizers that target the cardiac troponin complex.
Robertson et al. (2010)
6 more