› 2kir

Solution NMR

Solution structure of a designer toxin, mokatoxin-1

Released:
DOI: 10.2210/pdb2kir/pdb
PDB entry 2kir coloured by chain, ensemble of 20 models, front view.
PDB entry 2kir coloured by chain, ensemble of 20 models, side view.
PDB entry 2kir coloured by chain, ensemble of 20 models, top view.
Source organism: synthetic construct
Primary publication:
A designer ligand specific for Kv1.3 channels from a scorpion neurotoxin-based library.
Takacs Z, Toups M, Kollewe A, Johnson E, Cuello LG, Driessens G, Biancalana M, Koide A, Ponte CG, Perozo E, Gajewski TF, Suarez-Kurtz G, Koide S, Goldstein SA
Proc Natl Acad Sci U S A 106 22211-6 (2009)
PMID: 20007782

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-162823 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Designer toxin Chain: A
Molecule details ›
Chain: A
Length: 34 amino acids
Theoretical weight: 3.89 KDa
Source organism: synthetic construct
Expression system: Escherichia coli

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

8 review citations

Scorpion venom components as potential candidates for drug development.
Ortiz et al. (2015)
7 more

4 mentions without citation

Discovery of KV 1.3 ion channel inhibitors: Medicinal chemistry approaches and challenges.
Gubič et al. (2021)
3 more