› 2kiu

Solution NMR

Solution structure and backbone dynamics of the DNA-binding domain of FOXP1: Insight into its domain swapping

Released:
DOI: 10.2210/pdb2kiu/pdb
PDB entry 2kiu coloured by chain, ensemble of 20 models, front view.
PDB entry 2kiu coloured by chain, ensemble of 20 models, side view.
PDB entry 2kiu coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Solution structure and backbone dynamics of the DNA-binding domain of FOXP1: insight into its domain swapping and DNA binding.
Chu YP, Chang CH, Shiu JH, Chang YT, Chen CY, Chuang WJ
Protein Sci 20 908-24 (2011)
PMID: 21416545

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190565 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Forkhead box protein P1 Chain: A
Molecule details ›
Chain: A
Length: 87 amino acids
Theoretical weight: 10.54 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9H334 (Residues: 462-548; Coverage: 13%)
Gene names: FOXP1, HSPC215
Sequence domains: Forkhead domain
Structure domains: Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: distance geometry, simulated annealing
Expression system: Escherichia coli

Quick links

Citations

16 citation in other articles

Pan-Cancer Analysis of Mutation Hotspots in Protein Domains.
Miller et al. (2015)
15 more

14 mentions without citation

Molecular networks of FOXP family: dual biologic functions, interplay with other molecules and clinical implications in cancer progression.
Kim et al. (2019)
13 more