› 2kkg

Solution NMR

NMR structure of the octarepeat region of prion protein bound to pentosan polysulfate

Released:
DOI: 10.2210/pdb2kkg/pdb
PDB entry 2kkg coloured by chain, ensemble of 20 models, front view.
PDB entry 2kkg coloured by chain, ensemble of 20 models, side view.
PDB entry 2kkg coloured by chain, ensemble of 20 models, top view.
Source organism: Mesocricetus auratus
Primary publication:
Structure of the flexible amino-terminal domain of prion protein bound to a sulfated glycan.
Taubner LM, Bienkiewicz EA, Copié V, Caughey B
J Mol Biol 395 475-90 (2010)
PMID: 19913031

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-137558 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Major prion protein Chain: A
Molecule details ›
Chain: A
Length: 85 amino acids
Theoretical weight: 8.7 KDa
Source organism: Mesocricetus auratus
Expression system: Escherichia coli
UniProt:
  • Canonical: P04273 (Residues: 23-106; Coverage: 36%)
Gene names: PRNP, PRP

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing, molecular dynamics
Expression system: Escherichia coli

Quick links

Citations

9 review citations

Polyproline-II helix in proteins: structure and function.
Adzhubei et al. (2013)
8 more

3 mentions without citation

Structure of the flexible amino-terminal domain of prion protein bound to a sulfated glycan.
Taubner et al. (2010)
2 more