› 2kld

Solution NMR

Solution Structure of the Calcium Binding Domain of the C-terminal Cytosolic Domain of Polycystin-2

Released:
DOI: 10.2210/pdb2kld/pdb
PDB entry 2kld coloured by chain, ensemble of 10 models, front view.
PDB entry 2kld coloured by chain, ensemble of 10 models, side view.
PDB entry 2kld coloured by chain, ensemble of 10 models, top view.
Source organism: Homo sapiens
Primary publication:
NMR-assignments of a cytosolic domain of the C-terminus of polycystin-2.
Schumann FH, Hoffmeister H, Schmidt M, Bader R, Besl E, Witzgall R, Kalbitzer HR
Biomol NMR Assign 3 141-4 (2009)
PMID: 19636966

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171759 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Polycystin-2 Chain: A
Molecule details ›
Chain: A
Length: 123 amino acids
Theoretical weight: 14.02 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q13563 (Residues: 680-796; Coverage: 12%)
Gene names: PKD2, TRPP2
Structure domains: EF-hand

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: restrained molecular dynamics, simulated annealing
Expression system: Escherichia coli

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Citations

1 citations in other articles

Polycystin-1 is required for stereocilia structure but not for mechanotransduction in inner ear hair cells.
Steigelman et al. (2011)

3 mentions without citation

Ca2+-dependent conformational changes in a C-terminal cytosolic domain of polycystin-2.
Schumann et al. (2009)
2 more