› 2km3

Solution NMR

Structure of an intramolecular G-quadruplex containing a G.C.G.C tetrad formed by human telomeric variant CTAGGG repeats

Released:
DOI: 10.2210/pdb2km3/pdb
PDB entry 2km3 coloured by chain, ensemble of 10 models, front view.
PDB entry 2km3 coloured by chain, ensemble of 10 models, side view.
PDB entry 2km3 coloured by chain, ensemble of 10 models, top view.
Source organism: Synthetic construct
Primary publication:
Sequence variant (CTAGGG)n in the human telomere favors a G-quadruplex structure containing a G.C.G.C tetrad.
Lim KW, Alberti P, Guédin A, Lacroix L, Riou JF, Royle NJ, Mergny JL, Phan AT
Nucleic Acids Res 37 6239-48 (2009)
PMID: 19692585

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-115489 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
DNA (5'-D(*AP*GP*GP*GP*CP*TP*AP*GP*GP*GP*CP*TP*AP*GP*GP*GP*CP*TP*AP*GP*GP*G)-3') Chain: A
Molecule details ›
Chain: A
Length: 22 nucleotides
Theoretical weight: 6.94 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: DGSA-distance geometry simulated annealing, molecular dynamics, matrix relaxation
Expression system: Not provided

Quick links

Citations

10 review citations

Human telomeric G-quadruplex: structures of DNA and RNA sequences.
Phan AT. (2010)
9 more

13 mentions without citation

Sequence variant (CTAGGG)n in the human telomere favors a G-quadruplex structure containing a G.C.G.C tetrad.
Lim et al. (2009)
12 more