› 2km6

Solution NMR

NMR structure of the NLRP7 Pyrin domain

Released:
DOI: 10.2210/pdb2km6/pdb
PDB entry 2km6 coloured by chain, ensemble of 20 models, front view.
PDB entry 2km6 coloured by chain, ensemble of 20 models, side view.
PDB entry 2km6 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Three-dimensional structure of the NLRP7 pyrin domain: insight into pyrin-pyrin-mediated effector domain signaling in innate immunity.
Pinheiro AS, Proell M, Eibl C, Page R, Schwarzenbacher R, Peti W
J Biol Chem 285 27402-27410 (2010)
PMID: 20547486

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-186766 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
NACHT, LRR and PYD domains-containing protein 7 Chain: A
Molecule details ›
Chain: A
Length: 106 amino acids
Theoretical weight: 12.36 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8WX94 (Residues: 1-96; Coverage: 10%)
Gene names: NALP7, NLRP7, NOD12, PYPAF3
Sequence domains: PAAD/DAPIN/Pyrin domain
Structure domains: Death Domain, Fas

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 91%
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

14 review citations

An Update on PYRIN Domain-Containing Pattern Recognition Receptors: From Immunity to Pathology.
Ratsimandresy et al. (2013)
13 more

17 mentions without citation

Inhibiting the inflammasome: one domain at a time.
Dorfleutner et al. (2015)
16 more