› 2kma

Solution NMR

NMR structure of the F0F1 double domain (residues 1-202) of the talin ferm domain

Released:
DOI: 10.2210/pdb2kma/pdb
PDB entry 2kma coloured by chain, ensemble of 20 models, front view.
PDB entry 2kma coloured by chain, ensemble of 20 models, side view.
PDB entry 2kma coloured by chain, ensemble of 20 models, top view.
Source organism: Mus musculus
Primary publication:
Structure of a double ubiquitin-like domain in the talin head: a role in integrin activation.
Goult BT, Bouaouina M, Elliott PR, Bate N, Patel B, Gingras AR, Grossmann JG, Roberts GC, Calderwood DA, Critchley DR, Barsukov IL
EMBO J 29 1069-80 (2010)
PMID: 20150896

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150641 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Talin-1 Chain: A
Molecule details ›
Chain: A
Length: 178 amino acids
Theoretical weight: 20.69 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P26039 (Residues: 1-202; Coverage: 7%)
Gene names: Tln, Tln1
Sequence domains: N-terminal or F0 domain of Talin-head FERM
Structure domains: Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: SIMULATED ANNEALING, MOLECULAR DYNAMICS, TORSION ANGLE DYNAMICS
Expression system: Escherichia coli

Quick links

Citations

33 review citations

Talins and kindlins: partners in integrin-mediated adhesion.
Calderwood et al. (2013)
32 more

3 mentions without citation

The Structure of the talin head reveals a novel extended conformation of the FERM domain.
Elliott et al. (2010)
2 more