› 2kmu

Solution NMR

RecQL4 Amino-terminal Domain

Released:
DOI: 10.2210/pdb2kmu/pdb
PDB entry 2kmu coloured by chain, ensemble of 20 models, front view.
PDB entry 2kmu coloured by chain, ensemble of 20 models, side view.
PDB entry 2kmu coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
The N-terminus of the human RecQL4 helicase is a homeodomain-like DNA interaction motif.
Ohlenschläger O, Kuhnert A, Schneider A, Haumann S, Bellstedt P, Keller H, Saluz HP, Hortschansky P, Hänel F, Grosse F, Görlach M, Pospiech H
Nucleic Acids Res 40 8309-24 (2012)
PMID: 22730300

Function and Biology Details

Reaction catalysed: 
ATP + H(2)O = ADP + phosphate
Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131738 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
ATP-dependent DNA helicase Q4 Chain: A
Molecule details ›
Chain: A
Length: 56 amino acids
Theoretical weight: 6.85 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O94761 (Residues: 1-54; Coverage: 5%)
Gene names: RECQ4, RECQL4
Sequence domains: DNA replication and checkpoint protein
Structure domains: Arc Repressor Mutant, subunit A

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 79%
Refinement method: DGSA-distance geometry simulated annealing
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

8 review citations

Mechanisms and regulation of DNA replication initiation in eukaryotes.
Parker et al. (2017)
7 more

2 mentions without citation

The N-terminus of the human RecQL4 helicase is a homeodomain-like DNA interaction motif.
Ohlenschläger et al. (2012)
1 more