› 2kni

Solution NMR

High-resolution solution structure of the ASIC1a blocker PcTX1

Released:
DOI: 10.2210/pdb2kni/pdb
PDB entry 2kni coloured by chain, ensemble of 25 models, front view.
PDB entry 2kni coloured by chain, ensemble of 25 models, side view.
PDB entry 2kni coloured by chain, ensemble of 25 models, top view.
Source organism: Psalmopoeus cambridgei
Primary publication:
A dynamic pharmacophore drives the interaction between Psalmotoxin-1 and the putative drug target acid-sensing ion channel 1a.
Saez NJ, Mobli M, Bieri M, Chassagnon IR, Malde AK, Gamsjaeger R, Mark AE, Gooley PR, Rash LD, King GF
Mol Pharmacol 80 796-808 (2011)
PMID: 21825095

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-158030 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Psalmotoxin-1 Chain: A
Molecule details ›
Chain: A
Length: 41 amino acids
Theoretical weight: 4.79 KDa
Source organism: Psalmopoeus cambridgei
Expression system: Escherichia coli
UniProt:
  • Canonical: P60514 (Residues: 1-40; Coverage: 100%)
Structure domains: Laminin

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 85%
Refinement method: torsion angle dynamics
Expression system: Escherichia coli

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Citations

17 review citations

International Union of Basic and Clinical Pharmacology. XCI. structure, function, and pharmacology of acid-sensing ion channels and the epithelial Na+ channel.
Kellenberger et al. (2015)
16 more

7 mentions without citation

Animal, Herb, and Microbial Toxins for Structural and Pharmacological Study of Acid-Sensing Ion Channels.
Osmakov et al. (2020)
6 more