› 2knu

Solution NMR

Solution structure of the transmembrane proximal region of the hepatis C virus E1 glycoprotein

Released:
DOI: 10.2210/pdb2knu/pdb
PDB entry 2knu coloured by chain, ensemble of 10 models, front view.
PDB entry 2knu coloured by chain, ensemble of 10 models, side view.
PDB entry 2knu coloured by chain, ensemble of 10 models, top view.
Source organism: Hepacivirus C
Primary publication:
Structural characterization of the transmembrane proximal region of the hepatitis C virus E1 glycoprotein.
Spadaccini R, D'Errico G, D'Alessio V, Notomista E, Bianchi A, Merola M, Picone D
Biochim Biophys Acta 1798 344-53 (2010)
PMID: 19891955

Function and Biology Details

Reactions catalysed: 
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
Hydrolysis of four peptide bonds in the viral precursor polyprotein, commonly with Asp or Glu in the P6 position, Cys or Thr in P1 and Ser or Ala in P1'.
NTP + H(2)O = NDP + phosphate
ATP + H(2)O = ADP + phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-169895 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Envelope glycoprotein E1 Chain: A
Molecule details ›
Chain: A
Length: 29 amino acids
Theoretical weight: 3.33 KDa
Source organism: Hepacivirus C
Expression system: Not provided
UniProt:
  • Canonical: Q03463 (Residues: 314-342; Coverage: 1%)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 53%
Refinement method: torsion angle dynamics
Expression system: Not provided

Quick links

Citations

4 review citations

Protein-driven membrane stresses in fusion and fission.
Kozlov et al. (2010)
3 more

6 mentions without citation

Role of Hepatitis C Virus Envelope Glycoprotein E1 in Virus Entry and Assembly.
Tong et al. (2018)
5 more