› 2ko2

Solution NMR

NOGO66

Released:
DOI: 10.2210/pdb2ko2/pdb
PDB entry 2ko2 coloured by chain, ensemble of 10 models, front view.
PDB entry 2ko2 coloured by chain, ensemble of 10 models, side view.
PDB entry 2ko2 coloured by chain, ensemble of 10 models, top view.
Source organism: Mus musculus
Primary publication:
Protein folding at the membrane interface, the structure of Nogo-66 requires interactions with a phosphocholine surface.
Vasudevan SV, Schulz J, Zhou C, Cocco MJ
Proc Natl Acad Sci U S A 107 6847-51 (2010)
PMID: 20351248

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189368 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Reticulon-4 Chain: A
Molecule details ›
Chain: A
Length: 79 amino acids
Theoretical weight: 9.14 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q99P72 (Residues: 1025-1090; Coverage: 6%)
Gene names: Kiaa0886, Nogo, Rtn4
Sequence domains: Reticulon
Structure domains: Single alpha-helices involved in coiled-coils or other helix-helix interfaces

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli BL21

Quick links

Citations

3 review citations

Nogo-A represses anatomical and synaptic plasticity in the central nervous system.
Kempf et al. (2013)
2 more

3 mentions without citation

Protein folding at the membrane interface, the structure of Nogo-66 requires interactions with a phosphocholine surface.
Vasudevan et al. (2010)
2 more