› 2kog

Solution NMR

lipid-bound synaptobrevin solution NMR structure

Released:
DOI: 10.2210/pdb2kog/pdb
PDB entry 2kog coloured by chain, ensemble of 20 models, front view.
PDB entry 2kog coloured by chain, ensemble of 20 models, side view.
PDB entry 2kog coloured by chain, ensemble of 20 models, top view.
Source organism: Rattus norvegicus
Primary publication:
Dynamic structure of lipid-bound synaptobrevin suggests a nucleation-propagation mechanism for trans-SNARE complex formation.
Ellena JF, Liang B, Wiktor M, Stein A, Cafiso DS, Jahn R, Tamm LK
Proc Natl Acad Sci U S A 106 20306-11 (2009)
PMID: 19918058

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-158934 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Vesicle-associated membrane protein 2 Chain: A
Molecule details ›
Chain: A
Length: 119 amino acids
Theoretical weight: 12.99 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: P63045 (Residues: 1-116; Coverage: 100%)
Gene names: Syb2, Vamp2
Sequence domains: Synaptobrevin
Structure domains: Single alpha-helices involved in coiled-coils or other helix-helix interfaces

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

13 review citations

The Multifaceted Role of SNARE Proteins in Membrane Fusion.
Han et al. (2017)
12 more

19 mentions without citation

SNARE Modulators and SNARE Mimetic Peptides.
Khvotchev et al. (2022)
18 more