› 2kow

Solution NMR

Structure of a two-G-tetrad basket-type intramolecular G-quadruplex formed by Giardia telomeric repeat d(TAGGG)4 in K+ solution (with G18-to-INO substitution)

Released:
DOI: 10.2210/pdb2kow/pdb
PDB entry 2kow coloured by chain, ensemble of 10 models, front view.
PDB entry 2kow coloured by chain, ensemble of 10 models, side view.
PDB entry 2kow coloured by chain, ensemble of 10 models, top view.
Source organism: Synthetic construct
Primary publication:
Giardia telomeric sequence d(TAGGG)4 forms two intramolecular G-quadruplexes in K+ solution: effect of loop length and sequence on the folding topology.
Hu L, Lim KW, Bouaziz S, Phan AT
J Am Chem Soc 131 16824-31 (2009)
PMID: 19874015

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-115495 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
DNA (5'-D(*TP*AP*GP*GP*GP*TP*AP*GP*GP*GP*TP*AP*GP*GP*GP*TP*AP*IP*GP*G)-3') Chain: A
Molecule details ›
Chain: A
Length: 20 nucleotides
Theoretical weight: 6.36 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: DGSA-distance geometry simulated annealing, molecular dynamics, matrix relaxation
Expression system: Not provided

Quick links

Citations

9 review citations

NMR spectroscopy of G-quadruplexes.
Adrian et al. (2012)
8 more

5 mentions without citation

Secondary structural choice of DNA and RNA associated with CGG/CCG trinucleotide repeat expansion rationalizes the RNA misprocessing in FXTAS.
Ajjugal et al. (2021)
4 more