› 2kqh

Solution NMR

A G-rich sequence within the c-kit oncogene promoter forms a parallel G-quadruplex having asymmetric G-tetrad dynamics

Released:
DOI: 10.2210/pdb2kqh/pdb
PDB entry 2kqh coloured by chain, ensemble of 10 models, front view.
PDB entry 2kqh coloured by chain, ensemble of 10 models, side view.
PDB entry 2kqh coloured by chain, ensemble of 10 models, top view.
Source organism: Synthetic construct
Primary publication:
A G-rich sequence within the c-kit oncogene promoter forms a parallel G-quadruplex having asymmetric G-tetrad dynamics.
Hsu ST, Varnai P, Bugaut A, Reszka AP, Neidle S, Balasubramanian S
J Am Chem Soc 131 13399-409 (2009)
PMID: 19705869

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-115499 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
5'-D(*CP*GP*GP*GP*CP*GP*GP*GP*CP*GP*CP*GP*AP*GP*GP*GP*AP*GP*GP*GP*T)-3' Chain: A
Molecule details ›
Chain: A
Length: 21 nucleotides
Theoretical weight: 6.65 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand K 2 x K
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this NMR entry.
Refinement method: simulated annealing, molecular dynamics
Expression system: Not provided

Quick links

Citations

17 review citations

Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?
Balasubramanian et al. (2011)
16 more

2 mentions without citation

Polarizable Molecular Dynamics Simulations of Two c-kit Oncogene Promoter G-Quadruplexes: Effect of Primary and Secondary Structure on Loop and Ion Sampling.
Salsbury et al. (2020)
1 more