› 2kso

Solution NMR

EphA2:SHIP2 SAM:SAM complex

Released:
DOI: 10.2210/pdb2kso/pdb
PDB entry 2kso coloured by chain, ensemble of 15 models, front view.
PDB entry 2kso coloured by chain, ensemble of 15 models, side view.
PDB entry 2kso coloured by chain, ensemble of 15 models, top view.
Source organism: Homo sapiens
Entry authors: Hota PK, Preeti C, Stetzik L, Kim S, Wang B, Lee H, Buck M

Function and Biology Details

Reactions catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
1-phosphatidyl-1D-myo-inositol 3,4,5-triphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 3,4-diphosphate + phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127448 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Ephrin type-A receptor 2 Chain: A
Molecule details ›
Chain: A
Length: 82 amino acids
Theoretical weight: 9.4 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P29317 (Residues: 908-972; Coverage: 7%)
Gene names: ECK, EPHA2
Sequence domains: SAM domain (Sterile alpha motif)
Structure domains: Transcription Factor, Ets-1
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 Chain: B
Molecule details ›
Chain: B
Length: 76 amino acids
Theoretical weight: 8.67 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O15357 (Residues: 1200-1258; Coverage: 5%)
Gene names: INPPL1, SHIP2
Sequence domains: SAM domain (Sterile alpha motif)
Structure domains: Transcription Factor, Ets-1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli

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