› 2ktz

Solution NMR

Inhibitor Induced Structural Change in the HCV IRES Domain IIa RNA

Released:
DOI: 10.2210/pdb2ktz/pdb
PDB entry 2ktz coloured by chain, ensemble of 10 models, front view.
PDB entry 2ktz coloured by chain, ensemble of 10 models, side view.
PDB entry 2ktz coloured by chain, ensemble of 10 models, top view.
Source organism: Hepacivirus C
Primary publication:
Inhibitor-induced structural change in the HCV IRES domain IIa RNA.
Paulsen RB, Seth PP, Swayze EE, Griffey RH, Skalicky JJ, Cheatham TE, Davis DR
Proc Natl Acad Sci U S A 107 7263-8 (2010)
PMID: 20360559

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-196433 (preferred)
Entry contents:
1 distinct RNA molecule
Macromolecule:
HCV IRES Domain IIa RNA Chain: A
Molecule details ›
Chain: A
Length: 38 nucleotides
Theoretical weight: 12.12 KDa
Source organism: Hepacivirus C
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand ISH 1 x ISH
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: molecular dynamics
Expression system: Not provided

Quick links

Citations

13 review citations

Allostery in disease and in drug discovery.
Nussinov et al. (2013)
12 more

4 mentions without citation

Genome-wide mapping of SARS-CoV-2 RNA structures identifies therapeutically-relevant elements.
Manfredonia et al. (2020)
3 more